British Society of Cutaneous Allergy (BCSA)


What are the aims of this patient information leaflet?

This leaflet has been written to help you understand more about your contact allergy. It tells you what a contact allergy is, what causes this allergy and what you can do about it.

What is contact allergy?

Dermatitis, also known as eczema, describes a type of inflammation of the skin. Contact dermatitis or contact eczema is a term used when this inflammation is caused by direct or indirect skin contact with something in your environment. Allergic contact dermatitis occurs when your immune system causes allergy to a very specific chemical or substance that has been in contact with the skin.

What causes your specific allergy?

Your patch tests indicate that you have a contact allergy to methyldibromoglutaronitrile.

What is methyldibromoglutaronitrile?

Methyldibromoglutaronitrile is a preservative. It is also known as dibromodicyanobutane, Euxyl K 400 and Tektamer 38.

What are some products that contain methyldibromoglutaronitrile?

  • Cosmetics and shampoos (outside the EU)
  • Detergents and washing up liquid
  • Fabric softeners
  • Glues, including those attaching labels to jars
  • Polishes
  • Veterinary products, eg shampoos.


  • Glues and adhesives
  • Cutting oils, coolants and metalworking fluids
  • Wood preservatives
  • Car care products
  • Latex paints.

In 2005, the European Union, banned the use of methyldibromoglutaronitrile in stay-on cosmetic products, and then later in 2007 also in rinse-off products.

Remember, always check the label, these lists can never be complete and ingredients change.

How can I manage my allergy?

This means that you should avoid putting products containing methyldibromoglutaronitrile onto your skin in the future.

Self-care (what can I do?)

Always check the ingredient listing on the product, package or package insert as these lists can never be complete and ingredients change. This is particularly important for any products purchased outside the EU where some allergens may not be banned.

Created: 2016